17α-Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α
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چکیده
منابع مشابه
Changes in Dietary Fat Content Rapidly Alters the Mouse Plasma Coagulation Profile without Affecting Relative Transcript Levels of Coagulation Factors
BACKGROUND Obesity is associated with a hypercoagulable state and increased risk for thrombotic cardiovascular events. OBJECTIVE Establish the onset and reversibility of the hypercoagulable state during the development and regression of nutritionally-induced obesity in mice, and its relation to transcriptional changes and clearance rates of coagulation factors as well as its relation to chang...
متن کاملEXPERIMENTAL STUDY Estrogen increases coagulation factor V mRNA levels via both estrogen receptor-a and -b in murine bone marrow/bone
Objectives: Both oral estrogen-based hormone-replacement therapy and contraceptives increase the risk of venous thromboembolism. Several circulating factors involved in coagulation/fibrinolysis are expressed mainly in the liver whilst some are expressed in extrahepatic tissues, including bone marrow. The aim of this study was to identify estrogen-responsive target genes involved in the pathogen...
متن کاملComparing Methods of 17α-ethinylestradiol (EE2) Determination in Surface Water
We compared methods of determination of 17α-ethinyloestradiol (EE2) in surface water in Kielce, Poland. EE2 plays a role as a contraception agent and it is commonly used as an active agent in contraception pills. During studies three methods of EE2 determination were checked: TLC, HPLC, and ELISA assay. Samples of contaminated water were taken from eight points on four rivers crossing Kielce ci...
متن کاملXenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels
17β-estradiol (E2)-dependent estrogen receptor (ER) α intracellular concentration is a well recognized critical step in the pleiotropic effects elicited by E2 in several target tissues. Beside E2, a class of synthetic and plant-derived chemicals collectively named endocrine disruptors (EDs) or xenoestrogens bind to and modify both nuclear and extra-nuclear ERα activities. However, at the presen...
متن کاملCorrection: Xenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels
The corresponding authors are not noted in the HTML version of the paper. Dr. Filippo Acconcia ([email protected]) and Dr. Maria Marino ([email protected]) are the corresponding authors. Figure 5 is incorrect. Please see the corrected Figure 5 here. Copyright: ß 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribut...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2010
ISSN: 1538-7933
DOI: 10.1111/j.1538-7836.2010.03930.x